Backpacked downstream (opposite the way the trail guide reads) from Russell bridge on hwy 28 to hwy 76 (16.7 miles or 20 miles depending on what you read). Great hike, I would classify it as moderate instead of easy/moderate as there is fairly substantial topography. I utilized as many maps/guides as possible, and bottom line is that none of them are 100% accurate, although the topo map was probably the most useful. A few tips if you are hiking this direction on the trail:
1) There are only yellow diamond blazes for half the trail (Bartram Trail blazes), NOT a yellow diamond and silver diamond combo.
2) The chattooga trail has both the silver diamond blazes, and also new, neon-green rectangular blazes (2nd half of trail)
3) There are several points where you will be asking yourself which way to go, seeing multiple routes. In most circumstances when this occurs, cross the bridge, or if there is no bridge, follow the wider trail.
4) There is one particular point approaching Earl's Ford where you could either go straight and follow a yellow diamond blaze (which will lead to a dirt road - incorrect), or turn right and cross a large bridge. The blaze here is incorrect, and whomever placed it there was in error. Cross the bridge and follow yellow diamond blaze to the left past earl's ford.
I'm an experienced backpacker and must say I almost lost the trail on 3 occassions, and had to double back. Just remember, when in doubt, cross the bridge - that will help tremendously.
We saw very few people on the trail during our weekend hike, which was wonderful. You spend more time hiking in the hills than you do actually along the river. There are several campsites along the trail which we utilized. Started hiking around 3pm on Friday afternoon, and finished by 1pm Sunday. We took a very easy pace. This could be done in 2 days, 1 night for someone who wanted to crush it out and pack light. 2 nights was easy and enjoyable. Great trail, would do it again!