Don't Ignore Backwaters
The backwaters of the Mississippi River are extensive and give the fish a chance to get out of the current, especially in the spring when snowmelt on the northern portions of the river increase the flow rate. The bass need the calmer waters to spawn, making it even better fishing during the early part of the year, though it is exceptional year round.
The confluence of two streams has always been attractive to bass, and the Mississippi River's many tributaries offer plenty of locations from which to choose. It is especially effective if the tributary has relatively clear water. The muddy Mississippi provides cover as the bass look to ambush fish coming out of the smaller stream.
Fish Newly Flooded Areas
Though higher water may scare some anglers away from the Mississippi River, it can be one of the best times to fish. Bass often try to make use of the additional space and do not mind exploring new areas. Therefore, do not be afraid to fish in areas that were previously on dry ground.
Fish Around Common Features
Bass, no matter what body of water they are in, tend to congregate around brush, weeds and drop offs. The Mississippi River offers plenty of all three. While not all such features will hold fish, you should not have to look very long before you start getting results.
Use Live Bait
Live bait is a good way to catch bass, especially on the lower Mississippi. On that part of the river, visibility may be so low that many times lures are ineffective, simply because they aren't seen by the fish. Live bait not only can be seen, but also produces a scent that can attract nearby fish.