Interstate 40 runs west-east across Northern Arizona. Points of interest along I-40 include Petrified Forest National Park, Meteor Crater and the city of Flagstaff, Arizona.
Interstate 17 runs between Phoenix and Flagstaff. Points of interest along I-17 include Montezuma Castle National Monument and Red Rock Country near Sedona, Arizona, which features five state parks. Interstate 17 connects Interstate 10 and Interstate 40.
Interstate 10 runs east-west through southern Arizona. In addition to connecting Tucson and Phoenix, I-10 will take you near Fort Bowie Historical Site, Saguaro National Park and Picacho Peak State Park.
Interstate 8 runs east-west between Yuma and Interstate 10 at Cosa Grande. There are two state parks and the Fortuna Foothills near Yuma.
Interstate 19 runs from Tucson to Nogales, Mexico. Along the way, you can visit Tubac Presidio State Park and Tumacacori National Historical Park.
Getting to the Grand Canyon
None of the major highways access the Grand Canyon. To get there, Take I-40 to Highway 89 or 180. Continuing North on Highway 89 will take you to Pipe Spring National Monument, the Glen Canyon National Recreation Area and Page, Arizona, on the southern end of Lake Powell.